VGFacts

On my main setup, I've got two monitors. Some games for whatever reason like to have the mouse go between the two screens. A little annoying but not all that bad at first thought. Unfortunately, that gets really intrusive when playing things like Skyrim, Battlefield, anything that isn't x-com, hearthstone, or civilization. Anyone know a work-around?

Make sure you're running in full screen and not full screen windowed and you should be fine.

I am running in full screen unfortunately...
I've noticed some strange things actually. When I play something like Civ Beyond Earth, its not a problem if I choose the AMD optimized option, but it is if I choose the standard option.