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Two Princes in Nioh - DrakeVagabond - 11-10-2017
In the second version of the Tower of London, William can discover a piece of amrita with the voice of a child inside it. This child and the brother he is referring to is a reference to The Princes in the Tower paintings. They are expressions that frequently refer to Prince Edward V (11) and Richard (9), who mysteriously disappeared in the Tower of London in 1483, while their uncle, Richard III, usurped the throne.
Sources:
https://www.youtube.com/watch?v=D4JLwPoQsTE
http://www.historic-uk.com/HistoryUK/HistoryofEngland/The-Princes-in-the-Tower/